Cannabinol (CBN): A Sleeping Synergy
Many who have heard of the cannabinoid Cannabinol (CBN) have a negative impression of the compound, as it is typically believed to be a degraded compound that appears in old, poorly stored cannabis. However, this bleak perspective is not entirely accurate.
Unlike most cannabinoids, CBN rarely results from the decarboxylation of its acid form (CBNA). Most of the CBN found in cannabis is due to the degradation of THC, wherein the THC has oxidized to CBN. CBN is either non-psychoactive or very mildly psychoactive.
It reduces intraocular pressure in the eye (similar to D9THC), so it can be used in the treatment of Glaucoma without the psychoactive effects of THC. CBN is synergistic with THC for treatment purposes. CBN also fights free radicals in the bloodstream, and it performs similarly to THC in pain reduction treatments.
Initially, it was reported that CBN was a promising adjunct in the treatment of insomnia, but with the advent of a few small trials, sedative qualities have not been observed. Further study is required. Current evidence demonstrates that CBN reduces pain, inflammation and is anti-bacterial, while having little or no psychoactivity, making it a promising, alternative treatment to d9THC.